All the humans, with a couple of exceptions, get kicked off Pandora. It's thought this is because Jake prayed for help to Eywa.

In the final conflict between the humans and Na'vi, Pandora's wildlife essentially comes to the rescue.

Jake pilots an avatar to infiltrate the Na'vi to spy on them, but he ends up sympathizing with this majestic race and being drawn to the beguiling Neytiri, the princess of the clan. He ends up replacing his twin brother, who had a contract to go to Pandora and operate a Na'vi avatar, but was murdered. Jake Sully is a former Marine who lost use of his legs. Humans can then remotely pilot those clones, which are called avatars. Pandora's atmosphere is inhospitable to humans, so Earth scientists combined human and Na'vi DNA to create Na'vi clones. In particular, there's a concentration of unobtanium under what the Na'vi call their Hometree, a tree that has significant cultural and spiritual significance. The main conflict of the movie arises because a group called the Resources Development Administration, or RDA, wants to mine a mineral found on Pandora called unobtanium (yes, really). The year is 2154 and Earth has run down its own natural resources.

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